Fluorescent nucleobase analogues for base–base FRET in nucleic acids: synthesis, photophysics and applications

• Mattias Bood,
• Sangamesh Sarangamath,
• Moa S. Wranne,
• Morten Grøtli and
• L. Marcus Wilhelmsson

Beilstein J. Org. Chem. 2018, 14, 114–129, doi:10.3762/bjoc.14.7

• protection and phosphitylation using CEP-Cl generated the fully protected monomer ready for solid-phase synthesis [50]. The complete synthesis of the RNA building block of tCO was in this way achieved over five steps with a total yield of 28%, improved from the four step DNA building block synthesis of tCO

Total synthesis of a Streptococcus pneumoniae serotype 12F CPS repeating unit hexasaccharide

• Peter H. Seeberger,
• Claney L. Pereira and
• Subramanian Govindan

Beilstein J. Org. Chem. 2017, 13, 164–173, doi:10.3762/bjoc.13.19

• (Scheme 1, route B). Building block synthesis. The accessibility of differentially protected monosaccharide building blocks is a prerequisite for the successful total synthesis of any complex glycan. The synthesis of the mannosazide building block was the first challenge to be addressed. Installation of a

Photoswitchable precision glycooligomers and their lectin binding

• Daniela Ponader,
• Sinaida Igde,
• Marko Wehle,
• Katharina Märker,
• Mark Santer,
• David Bléger and
• Laura Hartmann

Beilstein J. Org. Chem. 2014, 10, 1603–1612, doi:10.3762/bjoc.10.166

• building block synthesis: N-Fmoc-para-(aminomethyl)phenylazobenzoic acid was prepared adapting literature procedures [19][23] (see Supporting Information File 1). General solid phase coupling protocols General coupling protocol: Commercially available trityl-tentagel-OH resin was modified with an

Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer

• Dirk Schmidt and
• Joachim Thiem

Beilstein J. Org. Chem. 2010, 6, No. 18, doi:10.3762/bjoc.6.18

• derivatives. Keywords: block synthesis; human milk oligosaccharides; sialyllacto-N-neotetraose epimer; sialyllacto-N-tetraose; trisaccharide thioglycoside donors; Introduction From an inspection of contemporary syntheses of biologically and medicinally relevant oligosaccharides, it is evident that the

• sialylations with respect to both stereochemical outcome and preparative input. The use of both procedures in a synergistic mode should also be considered. One of the general approaches ideally suited in such cases is the block synthesis method. Moreover, in recent years a number of combined chemical and